Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase

Authors

  • Liza Md Salleh Department of Bioprocess and Polymer Engineering, Universiti Teknologi Malaysia
  • Nohaniza Yusof Advanced Membrane Technology Research Centre (AMT, Universiti Teknologi Malaysia
  • Nor Asyiqin Bakeri Department of Bioprocess and Polymer Engineering, Universiti Teknologi Malaysia
Abstract:

This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays.  Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C.  The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays.  All data obtained were expressed as mean ± standard deviation for triplicate experiments.  One way analysis was used for statistical significance by using Statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software.  Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent.

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Journal title

volume 31  issue 8

pages  1308- 1317

publication date 2018-08-01

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